While studying for a doctorate in the National Science Base Class, he participated in completing the first batch of adult cell cloned pigs and green fluorescent protein transgenic pigs in China
A paper published in the international authoritative journal PNAS found that prepaternal diabetes can be passed on to future generations through epigenetic changes in male germ cells, revealing acquired sex
-like inheritance; a paper published in the Human Reproduction Update, a journal with high influence factors in the field of reproductive biology, conducted a study of more than 50 reproductive processes
cell-mediated epigenetics analysis found that germ cells can pass on information to their offspring through changes in methylated groups and non-coding RNA groups, which is the current popular fat.
Obesity, type 2 diabetes and other metabolic diseases provide a new theoretical basis. Won the first prize in natural science in the National Maternal and Child Health Science and Technology Award.
Research direction:
nMammalian reproduction and development
nResearch content:
1) Intergenerational transfer of epigenetic information
2) Interaction between epigenetic information and genetic information
3) The mechanism by which epigenetic information regulates reproductive development
nRepresentative paper:
Wei Y, Lang J, Zhang Q, Yang CR, Zhao ZA, Zhang Y, Du Y, Sun Y. DNA methylation analysis and editing in single mammalian
oocytes. Proc Natl Acad Sci U S A. 2019 May 14; 116(20): 9883-9892.
Wei Y, Yang CR, Wei YP, Zhao ZA, Hou Y, Schatten H, Sun QY*. Paternally induced transgenerational inheritance of
susceptibility to diabetes in mammals. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1873-8.
Wei Y, Schatten H, Sun QY*. Environmental epigenetic inheritance through gametes and implications for human
reproduction. Hum Reprod Update. 2015 Mar-Apr; 21(2): 194-208.
Wei Y, Yang CR, Wei YP, Ge ZJ, Zhao ZA, Zhang B, Hou Y, Schatten H, Sun QY*. Enriched environment-induced maternal
weight loss reprograms metabolic gene expression in mouse offspring. J Biol Chem. 2015 Feb 20. 290(8): 4604-19.
Wei Y, Zhang T, Wang YP, Schatten H, Sun QY*. Polar Bodies in Assisted Reproductive Technology: Current Progress and
Future Perspectives. Biol Reprod. 2015 Jan; 92(1): 19.
