2000.9-2004.7 Received a bachelor's degree from the School of Life Sciences, Shandong Normal University
2004.9-2011.1 Institute of Biochemistry and Cell Biology, Shanghai Academy of Life Sciences, China Academy of Sciences
Doctoral degree in biochemistry and molecular biology Supervisor: Academician Zhang Yonglian
2011.3-present Assistant Researcher, Department of Reproductive Medicine, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Research Results
Member of the Second Youth Committee of Reproductive Medicine Branch of Shanghai City Medical Association, and member of the Reproductive Medicine Laboratory of Shanghai City Society of Integrated Traditional Chinese and Western Medicine. As project leader, undertaking country
has one National Science Foundation Youth Fund and one general project, and has published more than 20 papers included in SCI. Invitedto be a member of the Journal of Clinical Endocrinology&
Metabolism, reviewed by magazines such as the Asian Journal of Andrology, Andrology and Oncotarget.
nResearch direction: Assisted reproduction
tResearch content: 1 Molecular mechanism of gamete development and maturation
2 Molecular mechanisms for the establishment and maintenance of endometrial receptivity
tRepresentative papers:
Shuanggang Hu*#, Ajuan Liang*, Guangxin Yao*, Xiangqi Li, Mei Zou, Jianwei Liu, Yun Sun#. The dynamic metabolomic
changes throughout mouse epididymal lumen fluid potentially contribute to sperm maturation. Andrology; 2018; 6(1):247-
255. (Co-corresponding author)
Guangxin Yao, Shuanggang Hu, Lu Yu, Yanfei Ru, Charlie Degui Chen, Qiang Liu, Yonglian Zhang. Genome-wide mapping of
in vivo ERα binding sites in male mouse efferent ductules. Endocrinology; 2017; 158(11):3724-3737.
Shuanggang Hu, Guangxin Yao, Yang Wang, Haijing Xu, Xiaowei Ji, Yaqiong He, Qinling Zhu, Zijiang Chen, Yun Sun.
Transcriptomic changes during the pre-receptive to receptive transition in human endometrium detected by RNA-Seq.
Journal of Clinical Endocrinology and Metabolisom; 2014; 99(12):E2744-53. doi: 10.1210/jc.2014-2155
Shuanggang Hu, Xiangqi Li, Chunhua Tang, Yun Sun, Yonglian Zhang. Isolation and characterization of detergent-resistant
membranes from rat spermatozoa. Asian Journal of Andrology; 2014; 16:790-791; doi: 10.4103/1008-682X.132979
Shuanggang Hu, Mei Zou, Guangxin Yao, Wubin Ma, Qinling Zhu, Xiangqi Li, Zijiang Chen, Yun Sun. Androgenic regulation of
beta-defensins in the mouse epididymis. Reproductive Biology and Endocrinology; 2014; 12:76. doi:10.1186/1477-7827-12-
76
Shuanggang Hu, Guangxin Yao, Xiangqi Li, Zijiang Chen, Yun Sun. Androgen receptor binding sites identified in mouse testis.
Acta Biochimica et Biophysica Sinica; 2013; 45(9):795-797.
Chunmei Wang*, Shuanggang Hu*, Yanfei Ru, Guangxin Yao, Wubin Ma, Yihua Gu, Chen Chu, Shoulin Wang, Zuomin Zhou,
Qiang Liu, Yuchuan Zhou, Yonglian Zhang. Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in
male mouse reproductive tract. International Journal of Molecular Sciences; 2013; 14(11):23188-202. (* Co-first author)
Wubin Ma, Shuanggang Hu, Guangxin Yao, Shengsong Xie, Qiang Liu, Xinxing Gao, Jun Zhang, Xingxu Huang, Yonglian
Zhang. An androgen-androgen receptor-miR-29a regulatory circuitry in mouse epididymis. Journal of Biological Chemistry;
2013; 11;288(41):29369-81
Li Ma, Heguo Yu, Zimei Ni, Shuanggang Hu, Wubun Ma, Chen Chu, Qiang Liu, Yonglian Zhang. Spink13, an Epididymis-
specific Gene of the Kazal-type Serine Protease Inhibitor (SPINK) Family, Is Essential for the Acrosomal Integrity and Male
Fertility. Journal of Biological Chemistry; 2013; 288(14):10154-65.
Shuanggang Hu, Han Du, Guangxin Yao, Yonglian Zhang. Molecular cloning and identification of mouse epididymis-specific
gene mHong1, the homologue of rat HongrES1. Asian Journal of Andrology; 2012; 14(4):626-34
Zhaoliang Fei, Shuanggang Hu, Liqin Xiao, Jiabin Zhou, Hua Diao, Heguo Yu, Shubei Fang, Yicheng Wang, Yinghan Wan,
Weigang Wang, Yuewei He, Chunmei Wang, Guojiang Xu, Zhugang Wang, Yonglian Zhang, Jian Fei. mBin1b transgenic mice
show enhanced resistance to epididymal infection by bacteria challenge. Genes & Immunity; 2012;13(6):445-51
Shuanggang Hu, Guangxin Yao, Xiaojun Guan, Zimei Ni, Wubin Ma, Elizabeth M. Wilson, Frank S. French, Qiang Liu, Yonglian
Zhang. Research resource: Genome-wide mapping of in vivo androgen receptor binding sites in mouse epididymis.
Molecular Endocrinology; 2010; 24:2392-405. (Faculty of 1000 highly rated)
