1. Ov-breaking needles in IVF technology

As one of the major achievements of modern medicine, IVF technology has brought hope to many families. In the process of ovulation promotion, the growth and maturation of folliclesare crucial. When the follicle develops to

At specific stages, specific drugs are needed to promote the final maturation of oocytes, rupture the follicles and release mature eggs. This drug is called the "egg breaking needle".

2. Why is the egg-breaking needle called the science of night needle?

The egg breaking needle is called the "trigger" in technical terms. Its function is to loosen the cumulus cells and facilitate the egg to fall off from the follicular wall, so as to facilitate the doctor's operation ofegg retrieval. However, why is this

The drug injection time for key steps is usually scheduled at night, which gives it the name "night needle"?

The reason why the oocyte breaking needle is injected at night is mainly because the timing of the egg retrieval operation is closely related to the night needle injection. The egg retrieval operation is usually performed 35 hours after the night needle injection. Given that egg retrieval

Time is a key element in the planning of subsequent laboratory work such as in vitro fertilization and embryo culture. Therefore, night injections are usually chosen tobe injected at night so that egg retrieval can be performed the next morning. Injection of night needle

Time is extremely critical and needs to be accurately controlled to minutes, and everyone's injection time is personalized. If the injection is too early, the follicles maynot have reached a fully mature state, resulting in the extracted eggs

Immature, which in turn affects the fertilization rate and cleavage rate; on the contrary, if the injection is too late, the egg may beluteinized in advance, its quality will be reduced, and may even be expelled early. Even if it is successfully obtained, it will be

Missed fertilization. Therefore, only when egg retrieval is carried out at the right timecan mature and high-quality eggs be obtained to the greatest extent possible.

3. Classification of ovum breaking needles

There are two types of ovo-breaking needles: HCG and Lupron, each with different application scenarios.

1. HCG

The full name is human chorionic gonadotropin. It is a glycoprotein derived from placental trophoblast cells and consists of dimers of two glycoproteins, alpha and beta. HCGplays an important role in women's pregnancy

It includes maintaining the secretion of estrogen and progesterone, promoting the formation of uterine decidua and maturation of placenta, andprotecting embryonic trophoblast cells from attack by maternal lymphocytes. In addition, HCG can also promote

Testosterone is secreted into the fetal testis, participates in male sexual differentiation, andbinds to the TSH receptor of maternal thyroid cells to activate thyroid function. In the field of obstetrics and gynecology, HCG is often used for pregnancy tests and passes

Test HCG levels to determine whether a woman is pregnant or has problems such as ectopic pregnancy, threatened abortion, and grapefetus. At the same time, HCG is useful in diagnosing pituitary disease, ovarian cyst, trophoblastic tumors and other diseases

is also important.

1. Lupron

Also known as leuprolide, is a gonadotropin drug that is a villous solid. Clinically, Lupron is often used to treat endometriosis,uterine fibroids with menorrhagia or lower abdominal pain

Premenopausal breast cancer and other diseases. In addition, it can also be used as a pre-medication for endometrial resection, helping toevenly thin the endometrium, reduce edema, and reduce the difficulty of surgery.

4. The difference between HCG and Lupron

In

the field of IVF, HCG and Lupron are often used as egg breaking needles to inject eggs before retrieval. However, IVF specialistsmay vary between HCG and Lupron

.

is different. The choice of egg breaking needle should be based on the female endocrine level and response to hormones, rather than random or blind selection.