Duringthe treatment of IVF, night acupuncture is regarded as the "first step" before egg retrieval. Many patients found that even patients who entered the cycle during the same period had significant differences in the time, type of drug and dose of night injections. The reason behind this is the embodiment of the concept of individualized treatment in reproductive medicine.
1. What is a “night injection”?
,.Its main components include chorionic gonadotropin (HCG) or short-acting gonadotropin releasing hormone agonist (GnRH-a).
The purpose of this injection is to simulate the peak level of luteinizing hormone (LH) before natural ovulation in the human body. This helps to promote the final maturation of the egg, makes the cumulus cells more loose, and facilitates the egg’s detachment from the follicle wall. All these factors contribute to creating optimal conditions for egg retrieval surgery.
From a biological perspective, the 34-36 hours after the injection for ovulation induction are the optimal period for egg maturation. During this time, egg retrieval surgery can yield eggs of suitable quality.
The development status of follicles is the primary basis. Doctors regularly monitor the size, number and growth rate of follicles through B-ultrasound.
▶ The condition of follicle development is the primary criterion.

B,.Generally, night acupuncture will be considered when at least one follicle has a diameter of ≥18mm or two follicles ≥17 mm. However, specific standards vary according to individual circumstances.
For patients with uneven follicle development, doctors may prescribe additional 1-2 days of ovulation-stimulating medication. Once more follicles have matured, the night injection can be scheduled.
▶Hormone levels are another crucial indicator.

,.The level of hormone directly affects the choice of drug types and doses for night acupuncture.
▶Individual differences need to be taken into account comprehensively.

,,,(,).For example, people with high ovarian responders may need to reduce their doses to prevent overstimulation, while people with poor responses may need to increase their doses or change medication.
Third, where exactly do the differences in timing for the night injections lie?
▶

(HCG),() GnRH-a().Different drugs have slightly different mechanisms of action and are suitable for patients under different conditions.
▶The difference in dosage is significant.

4000-10000IU,.In general, patients with more follicles and higher estrogen levels may have lower doses to reduce the risk of ovarian hyperstimulation syndrome (OHSS).
▶The injection time is accurate to the minute level.

,10.Too early injection may lead to immature follicles, and too late may cause overmature eggs, which will affect the egg retrieval effect.
▶Personalized arrangement of doses

,.This depends on the patient's ovarian function and how the body responds to the drug.
Fourth, why is individualization so important?
.An egg takes the lead in fertilization only when it has the right level of maturity. The individualized night needling plan ensures that a larger number of mature eggs can be obtained at the time of egg retrieval.
Reducing the risk of complications is equally important.Personalized night acupuncture regimen can significantly reduce the risk of complications such as ovarian hyperstimulation syndrome.
5. Precautions after nightinjection
Balance between rest and activity After injecting night injections, strenuous exercise should be avoided to prevent ovarian torsion or premature ovulation.
▶It’s important to balance rest and activity.

,.But you don't have to stay in bed for a long time, just rest properly.
▶Be sure to visit the doctor on time.

After the night injection, an egg retrieval procedure is necessary 34-36 hours later. It is essential to arrive at the hospital on time, otherwise the effectiveness of the egg retrieval may be affected.
▶Be cautious when using medications.

You should not take medication at will or stop medication after night injections. If you need medication for other diseases, you should consult a reproductive doctor in advance.
▶Pay attention to your body’s reactions.

If symptoms such as severe abdominal distension, abdominal pain, or difficulty breathing occur, it is necessary to seek medical attention promptly. These may be signs of ovarian hyperstimulation syndrome.
,,.Patients should fully trust the professional judgment of reproductive experts, strictly follow doctor's advice, and not compare plans with others. Each IVF plan is formulated "tailor-made" by doctors according to the patient's specific conditions. The purpose is to obtain the most ideal treatment effect while ensuring safety.