Elderly women undergoing IVF: Can we put an end to chromosomal abnormalities?

On the journey of life, every woman has the dream of becoming a mother. However, as time goes by, age often becomes a stumbling block on this dream. Especially forthose women who are reaching advanced age, naturally affected by

Pregnancy not only becomes difficult, but also comes with high risks such as chromosomal abnormalities. So, can IVF technology give them hope toavoid chromosomal abnormalities?

Why do chromosomal abnormalities occur when giving birth at an advanced age?

Chromosomes are the basic material that makes up the cell nucleus and the carrier of genetic material. The human body has a totalof 23 pairs of chromosomes (22 pairs of autosomes +1 pair of sex chromosomes). Each pair of chromosomes separates from each other when cells divide in numberand then enter different

In daughter cells, different pairs of chromosomes or genetic factors combine freely, and during the process of division and recombination,abnormalities such as chromosome deletion, translocation, increase in number or duplication often occur due to the influence of various factors, making

Chromosomal abnormalities occurred in the embryo.

The main causes of chromosomal abnormalities are

1. Decrease in quality of germ cells

As you age, the quality of eggs in a woman will gradually decrease, and egg cells may age. This aging can make eggs prone to problems such as geneticmutations and chromosomal abnormalities during fertilization. Male homosexual

People face the problem of declining sperm quality, and the sperm of older men may also carry abnormal chromosomes.

2. Chromosomes are not separated

The ability of germ cells to divide in elderly pregnant women will be reduced. During meiosis or early mitosis of the fertilized egg, it is easy to occur that a certain chromosome does not separate. This can causeabnormal chromosome numbers in the fetus after fertilization

Such as the commontrisomy 21 syndrome, trisomy 18 syndrome, etc.

3. Influence of external environmental factors

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Elderly pregnant women are more susceptible to external radiation, environmental pollution, viral infection and other factors during pregnancy. These environmental factors will further increase the probability of chromosome aberrations during embryonic development.

4. Decline of ovarian function

As you age, a woman's ovarian function gradually declines, resulting in a decrease in the number and quality of eggs. This decline not only affects the success rate of natural conception, but also increasesthe risk of chromatid abnormalities.

5. Family history of genetic diseases

If there is a family history of genetic diseases, such as chromosomal abnormality-related diseases, elderly pregnant women are also at increased risk of carrying abnormal chromosomal genes. These genetic factors may directly affectthe structure and number of chromophores in the embryo.

According to research data, the older a woman gets, the probability of fetal chromosomal abnormalities increases. For example, the probability of chromosomal abnormalities in the fetus of a 42-year-old woman is as high as 1/40, whilethe probability of chromosomal abnormalities in the fetus of a 35-year-old woman is only 1/1300.

Therefore, older women need to pay more attention to the risk of chromosomal abnormalities during pregnancy preparation and pregnancy, and take corresponding preventive measures.

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Canelderly womenavoid chromosomal abnormalities by doing IVF?

In order to reduce the risk of chromosomal abnormalities, elderly pregnant women can undergo a comprehensive health checkup when preparing for pregnancy and supplement folic acid during the first three months of pregnancy. At the same time, it is also very important to conduct regular prenatal screening anddiagnosis so that timely diagnosis can be made

Identify and handle chromosomal abnormalities. In addition, if conditions permit, elderly women can also consider choosing three-generation IVF technologyto screen embryos and genes before transplantation to further improve the quality of embryos

and reduce the risk of chromosomal abnormalities.

PGT-mgene detection is an important core technology for the third generation of IVF. For example, it detects the chromosome number and structure of blastocysts, and analyzes and compares whether embryos have chromosome deletions, duplications, and translocations. and other abnormalities. Diagnostic embryo is

Whether it carries a genetic defect gene or a genetic mutation that causes a specific disease, and then selects healthy and high-quality blastocyst from it for transplantation can effectively avoidfetal arrest, abortion, etc. caused by chromosomal abnormalities of the embryo, greatly increasing the number of women

Pregnancy rate while protecting the health of future generations.

Couples who have had embryonic chromosome abnormalities that led to miscarriage have a higher probability of having this problem when they become pregnant again. Therefore, it is recommended to use scientific methods to assist pregnancy. Only in this way can weeffectively avoid fetal arrest, abortion or deformed babies

During pregnancy, expectant mothers should also maintain good living habits, avoid staying up late, regular work and rest schedules, go to bed early and wake up early; Eat a reasonable diet, ensure balanced nutrition, and more

Eat vegetables andfruits, high-quality protein, etc., to provide sufficient nutrients for the growth and development of the fetus; stay away from radiation and harmful chemical substances, maintain a happy and comfortable mood, which is conducive to the growth of the fetus and avoidthe risk of fetal arrest and abortion.