Before embryo transfer, a certain understanding of the grading of embryos is needed. After all, embryos with higher grades have relatively better quality, and the development of embryos is a
The dynamic process usually requires the evaluation of the quality and development potential of the embryo at every stage of embryo development. The actual information provided to the patient is that the embryo develops to the cleavage stage
Scoring results for embryos (i.e., day 3 embryos) and blastocysts (day 5 to 6 embryos). The embryo scoring standards for different periods mentioned above are also different.
The embryo scoring on day 3 mainly considers the uniformity of embryo cell division and development speed. Too fast or too slow development is not ideal. It is generally believed that embryos with 6 to 10 cells will pass
often have good development potential; embryos with good homogeneity in cytoplasm have better quality; there is less cell debris (small cells smaller than the blastomere), that is, the smaller the degree of fragmentation, the higher the development potential of the embryo
Conversely, the quality of the embryo is poor. High blastomere homogeneity indicates good embryo quality.
The scoring standard for embryos in the blastocyst stage from the fifth to sixth days mainly takes into account that the embryo has begun to differentiate at this stage, with the appearance of three parts: blastocyst cavity, inner cell mass and trophoblast cells. wherein inner cells
The colony will develop into a fetus in the future, and the trophoblast cells will differentiate and develop into a placenta in the future, providing nutrition for the implantation and subsequent development of the embryo. Therefore, the scoring of blastocysts mainly considers the difference in the blastocyst
Development stage. At present, the blastocyst evaluation method proposed by Gardner is mainly used internationally, which divides blastocyst development into six periods based on whether the blastocyst cavity is incubated and the size of the blastocyst cavity. where 1 to
Stage 2 blastocysts are collectively referred to as early blastocysts (EB), and stages 3 to 6 blastocysts are divided into three grades: A, B, and C based on inner cell mass and trophoblastic cells. Among them, the number of A-level cells is large and closely arranged
The number of Class B cells is small and loosely arranged; the number of Class C cells is very small. Under normal circumstances, blastocysts with CC and above can be used for freezing or transfer, and blastocysts worse than CC are recommended to be abandoned. Whether it is
The score of the inner cell mass or trophoblast cells is higher. The more the number of cells and the closer the cells are arranged, the better the embryonic cells develop and the relatively better the quality of the embryo. Among them, the expansion of development stages ≥3
Open stage blastocysts predict better pregnancy outcomes. At present, blastocysts with a score of 3BB are generally classified> as high-quality blastocysts in clinical practice. The high-quality blastocysts on day 5 are 4AA, and the blastocysts on day 6 are of poor quality
Blastocyst on day 5.
The current scoring standard for cleavage stage embryos and blastocysts mainly evaluates embryos based on their appearance, which is a non-invasive evaluation method. However, although there are certain main principles for morphological evaluation methods
Observing, but it is also the most widely used scoring standard at present. However, in addition to the quality of the embryo, problems such as the condition of the woman's endometrium, chromosomes of both men and women, and the woman's immunity may affect the embryo
implantation and development. Therefore, the quality of embryos and the success rate of IVF need to be viewed objectively.
